Expression and prognostic significance of CD93 in blood vessels in colorectal cancer: an immunohistochemical analysis of 134 cases

Shuzhe Yang ¹, Zhongyuan Bai ², Fei Zhang ³

⁰Second Clinical Medical School, Shanxi Medical University, Taiyuan, China.

Bmc Gastroenterology +

|

February 18, 2025

View abstract on PubMed

Summary

CD93 is highly expressed in colorectal cancer (CRC) vessels and linked to immune cell infiltration. Detecting CD93 may predict vascular normalization and improve patient prognosis in CRC.

Area Of Science

Oncology
Vascular Biology
Immunology

Background

Tumor blood vessels are abnormal, impacting the tumor microenvironment.
CD93, a transmembrane receptor on tumor endothelial cells, shows prognostic value in some cancers.
The role of CD93 in colorectal cancer (CRC) vasculature and prognosis is currently unknown.

Purpose Of The Study

To investigate the expression of CD93 in CRC tissues.
To determine the correlation between CD93 expression and clinicopathological factors in CRC patients.
To assess the prognostic significance of CD93 in colorectal cancer.

Main Methods

Immunohistochemistry was used to detect CD93 expression in human CRC tissues.
Clinicopathological factors were analyzed in 134 CRC patients.
Correlation between CD93 expression and clinicopathological factors was examined.

Main Results

CD93 expression was elevated in CRC vessels compared to normal adjacent tissues.
Higher CD93 levels correlated with tumor site, microsatellite instability, and increased macrophage infiltration.
High CD93 expression was associated with potential tumor vasculature normalization and improved overall survival.

Conclusions

CD93 is highly expressed in CRC vasculature and associated with immune cell infiltration.
CD93 expression serves as a predictive biomarker for vascular normalization and patient prognosis in CRC.

Keywords:

CD93 Colorectal cancer Tumor microenvironment Tumor vascular normalization