Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration

The oral cavity is an open and complicated structure with a variety of factors affecting topical oral medications. The complicated physical and chemical surroundings of the oral cavity can influence the action of free drugs. Thus, the drug delivery system can serve as a support structure or carrier. Hydrogels are prospective tissue engineering biomaterials that demonstrate immense potential for oral tissue regeneration and drug delivery. Hydrogels are crosslinked polymer chains with a 3-dimensional network structure that can take up larger volumes of liquid and have a soft, porous structure that closely resembles living tissue. Hydrogels protect the active drug from systemic and topical elimination, increase the bioavailability and absorption into cells, and release or modify the therapeutic drug release immediately after dosing. In this review, we introduce the classification of hydrogels, introduce the application of hydrogels in oral diseases (periodontal disease, endodontics, oral mucosal disease, alveolar surgery, oral cancer, maxillofacial bone defects, and oral implantation), summarize the synthesis methods and the applications of hydrogels, and discuss the possible directions of the future development of hydrogels, which will provide a new idea for the formulation and production of a more advantageous and efficient topical oral drug delivery system.