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Updated: May 27, 2025
09:19
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
8.5K
Initial real-world experience with ribociclib in advanced breast cancer
Azhar Nawaz1,2, Jamal Zekri1,3,4, Haleem Rasool1,5
1King Faisal Specialist Hospital & Research Centre (Jeddah), Jeddah, Saudi Arabia.
Summary
Ribociclib combined with hormonal therapy showed strong progression-free survival (PFS) and overall survival (OS) in advanced breast cancer patients. However, adverse events led to higher discontinuation rates than in clinical trials.
Area of Science:
- Oncology
- Pharmacology
Background:
- CDK4/6 inhibitors like ribociclib are standard for advanced hormone receptor-positive, HER2-negative breast cancer.
- Combination with hormonal therapy is the recommended treatment approach.
Purpose of the Study:
- To assess the real-world effectiveness of ribociclib.
- To evaluate the safety and tolerance of ribociclib in breast cancer patients at our institution.
Main Methods:
- Retrospective analysis of 68 patients receiving >1 cycle of ribociclib (Dec 2018-Mar 2022).
- Intolerance assessed by adverse events (AEs), dose reduction, and discontinuation rates.
Main Results:
- Median progression-free survival (PFS) was 18 months; 84% were alive at 3 years (median overall survival [OS] not reached).
- Adverse events led to dose reduction in 44% and permanent discontinuation in 13.2% of patients.
- Objective response rate was 16.4% in evaluable patients.
Conclusions:
- Ribociclib with letrozole or fulvestrant demonstrated significant PFS and OS in a real-world setting.
- Higher rates of treatment discontinuation due to AEs were observed compared to clinical trials.
- Modest objective response rates were noted in heavily pretreated patients.
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