An update on implication of POSS-based nanocomposites in bone tissue engineering: a review

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Tissue Engineering

Background:

• Bone tissue engineering (TE) is advancing rapidly, utilizing synthetic scaffolds, cells, and growth factors.
• Porous scaffolds are crucial for cell integration, proliferation, and 3D bone tissue formation.
• Regenerative medicine seeks novel materials for treating tissue defects.

Purpose of the Study:

• To review the impact of polyhedral oligomeric silsesquioxane (POSS) on bone TE.
• To analyze POSS integration within Chitosan (CS), Hydroxyapatite (HA), and zeolite scaffolds.
• To evaluate the advantages and limitations of these POSS-modified materials for bone regeneration.

Main Methods:

• Literature review on POSS incorporation in biomaterials for bone TE.
• Analysis of scaffold fabrication methods involving POSS, CS, HA, and zeolite.
• Assessment of studies reporting on the biological properties and performance of these composite scaffolds.

Main Results:

• POSS incorporation can improve the biological properties of hybrid biomaterials.
• POSS-modified CS, HA, and zeolite scaffolds show potential for bone regeneration.
• Specific advantages and limitations of each material combination are discussed.

Conclusions:

• POSS holds promise for enhancing bone tissue engineering scaffolds.
• Further research is needed to fully elucidate the potential of POSS-modified composites.
• Optimizing scaffold design and material properties is key for successful clinical translation.