Eosinophilic Fasciitis: A Case Series

Eosinophilic fasciitis (EF) is a rare and frequently underdiagnosed condition, with limited representation in the scientific literature. Early and accurate diagnosis is critical to preventing the progression of the disease and the development of irreversible damage. EF is characterized by thickening and fibrosis of the subcutaneous fascia and skin, typically affecting the extremities, trunk, and neck, with peripheral eosinophilia occasionally observed. While most cases are considered idiopathic, a thorough evaluation is essential to rule out differential diagnoses or associated underlying conditions. The disease significantly impacts patients' daily activities and is associated with substantial morbidity. Management of EF primarily involves the use of corticosteroids and other immunosuppressive therapies. The majority of patients demonstrate favorable responses to treatment, particularly when intervention occurs before the onset of advanced fibrosis. In this paper, we present a case series involving four patients diagnosed and treated at our institution. We provide a detailed analysis of the diagnostic process, therapeutic approaches, and follow-up strategies employed, contributing to the broader understanding of this rare disease.