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Improving ungated steady-state cardiac perfusion using transition bands.

Jason K Mendes1, Johnathan V Le1,2, Andrew E Arai3

  • 1Utah Center for Advanced Imaging Research, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.

Magnetic Resonance in Medicine
|February 18, 2025
PubMed
Summary

This study introduces transition bands to ungated cardiovascular MRI sequences, improving myocardial perfusion quantification by minimizing motion-induced errors without affecting imaging efficiency or temporal resolution.

Keywords:
arterial input functioncardiac perfusionungated perfusion

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Medical Imaging Physics

Background:

  • Gated first-pass contrast-enhanced sequences are standard for cardiovascular MR perfusion.
  • Ungated steady-state sequences are necessary for some patients but prone to errors from cardiac motion and blood flow.
  • Existing methods may contain quantification errors due to disrupted magnetization steady state.

Purpose of the Study:

  • To eliminate tissue magnetization steady-state disruption in ungated cardiovascular MR perfusion imaging.
  • To improve perfusion quantification accuracy in challenging patient conditions.
  • To introduce a sequence modification without altering resolution or timing parameters.

Main Methods:

  • Simultaneously exciting two transition bands adjacent to the imaged region.
  • Using gradient dephasing and radiofrequency spoiling to null transition band signals.
  • Integrating transition bands into a 2D ungated steady-state radial FLASH sequence with simultaneous multiband imaging on a PRISMA 3T MRI scanner.

Main Results:

  • Transition bands effectively reduce magnetization steady-state disruption without introducing artifacts.
  • Myocardial blood flow maps show good uniformity and consistency with literature values.
  • Perfusion estimates align well with saturation-recovery methods.

Conclusions:

  • The proposed transition bands reduce quantification errors from blood flow and motion.
  • Image acquisition efficiency and temporal resolution remain unchanged.
  • This technique offers a viable solution for accurate ungated cardiovascular MR perfusion imaging.