Intermittent Binge-Intake Model in Mice
Sonia Ortega-Tinoco1, Rodrigo Acosta-Luna1, Leticia Verdugo-Díaz1
1Department of Physiology, Faculty of Medicine, Universidad Nacional Autónoma de México (UNAM).
Journal of Visualized Experiments : Jove
|February 18, 2025
Summary
Intermittent access to palatable foods like M&M's in mice triggers binge eating and anxiety. This feeding schedule, not continuous access, promotes overconsumption, aiding binge eating disorder research.
Area of Science:
- Neuroscience
- Behavioral Science
- Metabolic Research
Background:
- Obesity is a global health issue, with overeating of high-calorie foods being a major contributor.
- Binge eating disorder (BED) is a complex condition influenced by biological, psychological, and social factors, characterized by excessive consumption and often linked to anxiety.
Purpose of the Study:
- To develop a standardized mouse model for investigating binge eating disorder (BED) using a highly palatable food (HPF).
- To examine the effects of continuous versus intermittent access to HPF on eating behaviors and anxiety.
Main Methods:
- C57BL/6 mice were given continuous or intermittent access to M&M's (HPF) alongside standard chow.
- Feeding schedules were maintained for 26 days, with behavioral assessments conducted.
Main Results:
- Mice with intermittent access to HPF exhibited significant binge-eating behaviors and consumed more calories, primarily from the HPF.
- Intermittent HPF access induced anxiety-like behaviors in mice compared to continuous access and control groups.
Conclusions:
- Feeding schedules critically influence the overconsumption of palatable foods, highlighting the role of access patterns in exacerbating binge-eating tendencies.
- This mouse model offers a realistic approach to studying BED and its metabolic consequences, providing insights for therapeutic interventions.
