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![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Gold-catalyzed polyene cyclization and its application in the total synthesis of natural products
Ye Zhang1, Wen Bao1, Xiao-Ming Zhang1
1School of Pharmacy & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, Gansu, China. wangshh@lzu.edu.cn.
Abstract:
Polyene cyclization has emerged as a powerful tool for increasing molecular complexity. In recent years, gold-catalyzed polyene cyclization reactions have made significant progress, particularly in the total synthesis of complex polycyclic natural products with biological activity. Simultaneously constructing multiple stereogenic centers and core polycyclic ring structures, especially through the catalytic asymmetric reactions, greatly improves the efficiency of natural product synthesis. The alkynyl functional group can initiate polyene cyclization reactions, and the resulting vinyl moiety can facilitate subsequent functional group transformations, making it highly versatile. This review mainly summarizes the synthetic methodology of polyene cyclization reactions based on the underlying mechanisms and their applications in the total synthesis of polycyclic natural products.
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