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Ketoprofen and its lysine salt in managing children with fever: evidence emerging from comparative trials

Francesco Scaglione1, Giorgio Ciprandi2

  • 1Department of Oncology and Hemato-Oncology, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan, Milan, Italy.

Panminerva Medica
|February 18, 2025
PubMed

Insights

Ketoprofen and ketoprofen lysine salt (KLS) are effective fever reducers in children. These non-steroidal anti-inflammatory drugs (NSAIDs) offer a valuable alternative to ibuprofen and acetaminophen for managing pediatric fever.

Area of Science:

  • Pediatrics
  • Pharmacology
  • Infectious Diseases

Background:

  • Fever is a common physiological response to infection and inflammation.
  • While beneficial, fever can cause discomfort, necessitating symptomatic relief.
  • Antipyretics, including NSAIDs and acetaminophen, are used to manage fever.

Purpose of the Study:

  • To compare the efficacy of ketoprofen and ketoprofen lysine salt (KLS) against other antipyretics in pediatric populations.
  • To evaluate ketoprofen and KLS as management options for children experiencing fever.

Main Methods:

  • Review of comparative pediatric studies.
  • Analysis of clinical data on ketoprofen, KLS, ibuprofen, and acetaminophen efficacy.
  • Focus on symptom relief and safety profiles.

Main Results:

  • Ketoprofen and KLS demonstrated significant antipyretic effects in children.
  • Ketoprofen lysine salt (KLS) offers improved absorption and reduced side effects compared to acid ketoprofen.
  • Both ketoprofen and KLS were found to be valuable options for managing pediatric fever.

Conclusions:

  • Ketoprofen and KLS are effective and safe antipyretic options for pediatric use.
  • These agents provide a viable alternative to commonly used antipyretics like ibuprofen and acetaminophen.
  • Further research may explore long-term efficacy and specific indications for ketoprofen-based therapies in children.

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