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Biomarkers of Radioresistance in Head and Neck Cancer: A New Beginning
1Division of Radiation Oncology, The George Washington University, Washington, District of Columbia.
Abstract:
The development of biomarkers of radioresistance in head and neck cancer may help personalize treatment. This commentary puts in context the findings of a secondary analysis of NRG/RTOG 9512, a trial of fractionation in T2N0 glottic cancer, which observed that NFE2L2/KEAP1/CUL3 mutations are correlated with local recurrence and disease-free survival. See related article by Guan et al., p. 1615.
