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Fungal effector disables cathepsin-driven Toll immunity in insects

Rebecca J Tay1, Yen-Ping Hsueh2

  • 1Academia Sinica, Institute of Molecular Biology, Taipei 115, Taiwan.

Proceedings of the National Academy of Sciences of the United States of America
|February 18, 2025
PubMed
Abstract

No abstract available in PubMed .

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Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.