Age-related changes of activity of acid phosphatase in PHA-stimulated lymphocytes

Peripheral blood lymphocytes of 70-year-old individuals as well as spleen cells of 18-month-old Balb/c mice were characterized by diminished activity of acid phosphatase in relation to the activity of that enzyme in cells from young subjects. Simultaneously performed histochemical tests revealed that aging process in both species examined was accompanied by a reduction of the number of cells, disclosing the activity of acid phosphatase. Age-related differences with regard to the level of acid phosphatase became more pronounced after stimulation of cells with PHA. The decrease of acid phosphatase activity during aging is discussed in relation to the function of lymphocytes.