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Schistosoma mansoni: extramedullar eosinophil myelopoiesis induced by intraperitoneal glass implants in chronically
Abstract:
Intraperitoneal glass implants in mice with chronic Schistosoma mansoni infections induce intense local myeloid reactions involving essentially myeloid granulocytes. The same phenomenon is not observed in normal mice nor in mice with acute schistosomal infection. An association of myelopoiesis with differentiated macrophages mobilized on glass implants and with dense ameboid cells located inside myeloid foci was detected. A macrophage-dependent induction of this eosinophil reaction is postulated.
Insights
Chronic Schistosoma mansoni infection in mice triggers significant myeloid cell reactions around implants. Macrophages appear to drive this eosinophil response, a phenomenon not seen in acute infections or healthy mice.
Area of Science:
- Immunology
- Parasitology
- Cell Biology
Background:
- Schistosoma mansoni infections cause chronic inflammation.
- Foreign body reactions involve myeloid cells.
Purpose of the Study:
- To investigate the myeloid response to implants in chronic Schistosoma mansoni infection.
- To elucidate the role of macrophages in this specific immune reaction.
Main Methods:
- Intraperitoneal implantation of glass in mice.
- Induction of chronic Schistosoma mansoni infection.
- Histological analysis of myeloid reactions.
Main Results:
- Chronic S. mansoni infection induced intense local myeloid granulocyte reactions around implants.
- Normal mice and mice with acute infection did not show this phenomenon.
- Myelopoiesis was associated with macrophages and ameboid cells within myeloid foci.
Conclusions:
- A macrophage-dependent induction of the eosinophil reaction is suggested.
- The observed myeloid reaction is specific to chronic schistosomal infection states.