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Metastasis

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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Histology-specific prognostic significance of isolated tumor cells, micrometastases, and macrometastases in

Koji Matsuo¹, Joel Agarwal², Ling Chen²

¹Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Los Angeles General Medical Center, Los Angeles, CA, USA.

Gynecologic Oncology

|February 18, 2025

Summary

Tumor metastatic size, not location, significantly impacts endometrial cancer survival. Isolated tumor cells have varied prognostic value depending on histology, requiring further study in low-grade endometrioid types.

Keywords:

Endometrial cancer Histology Isolated tumor cells Macrometastasis Micrometastasis Survival

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Area of Science:

Gynecologic Oncology
Cancer Research
Pathology

Background:

Regional lymph node status is critical in endometrial cancer staging and prognosis.
Understanding the prognostic impact of metastatic size and location is essential for treatment planning.

Purpose of the Study:

To investigate the association between regional lymph node metastatic size and anatomical location and survival in endometrial cancer.
To analyze these associations based on specific tumor histology.

Main Methods:

Retrospective analysis of 87,904 patients with stage I-III endometrial cancer (2018-2021) from the National Cancer Database.
Multivariable Cox proportional hazard regression models were used to assess overall survival.
Stratification by histology: non-endometrioid/high-grade endometrioid vs. low-grade endometrioid.

Main Results:

Macro-metastasis (pelvic/para-aortic) significantly decreased overall survival compared to pelvic micro-metastasis in both histology groups.
Para-aortic micro-metastases showed similar survival to pelvic micro-metastases.
Isolated tumor cells had differential survival impacts: better survival in non-endometrioid/high-grade, but decreased survival in low-grade endometrioid histology compared to negative nodes.

Conclusions:

Tumor metastatic size appears more prognostic than anatomical location in endometrial cancer.
The prognostic significance of isolated tumor cells varies by histology and warrants further investigation, particularly in low-grade endometrioid endometrial cancer.