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Updated: Jul 11, 2026
09:04
Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
Published on: September 5, 2011
Cardiac function and neurological development in complicated monochorionic pregnancies: Current evidence and clinical
1Fetal Medicine, St George's University Hospitals NHS Foundation Trust, London, London, United Kingdom.
Early Human Development
|February 18, 2025
Summary
Monochorionic twin pregnancies have high risks. This review covers Twin-to-Twin Transfusion Syndrome, Selective Fetal Growth Restriction, and Twin Anemia Polycythemia Sequence, detailing their impact and management.
Area of Science:
- Maternal-Fetal Medicine
- Perinatology
- Twin Gestation Research
Background:
- Monochorionic twin pregnancies share a placenta, increasing risks of complications like TTTS, sFGR, and TAPS.
- These conditions cause significant cardiovascular and neurological adaptations and injuries in fetuses.
- Existing therapies improve survival but long-term outcomes require further investigation.
Purpose of the Study:
- To review the pathophysiology, cardiovascular, and neurological adaptations in TTTS, sFGR, and TAPS.
- To highlight the impact of these complications on twin pregnancies.
- To emphasize the need for specialized care and further research.
Main Methods:
- Review of existing literature on monochorionic twin pregnancy complications.
- Analysis of pathophysiology, cardiovascular adaptations, and neurological outcomes.
- Examination of current and emerging fetal therapies.
Main Results:
- TTTS leads to hemodynamic imbalance, cardiac dysfunction, and neurodevelopmental injury.
- sFGR results in cardiovascular and neurological disparities due to unequal placental sharing.
- TAPS causes chronic anemia/polycythemia, increasing risks of brain injury.
Conclusions:
- Specialized prenatal care, multidisciplinary management, and postnatal follow-up are crucial.
- Further research is needed to understand fetal adaptation and injury mechanisms.
- Refining diagnostic tools and therapeutic strategies is essential for improving outcomes.
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