Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperoxia reflects poor native cardiac function and demonstrates cardiac index-dependent associations with mortality in VA-ECMO patients.

European heart journal. Acute cardiovascular care·2026
Same author

Identifying Risk Factors for Readmission amongst Unhoused Burn Patients.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage.

The New England journal of medicine·2026
Same author

A Case Study of AI-Enabled Software as a Medical Device Cleared by the FDA for Assessing Hemorrhage Risk Index (APPRAISE-HRI) after Trauma.

NEJM AI·2026
Same author

The Current State of Acute Care Surgery Workforce and Practice Models: A Joint Statement by the American Association for the Surgery of Trauma, the American College of Surgeons Committee on Trauma, the Eastern Association for the Surgery of Trauma, and the Western Trauma Association.

Journal of the American College of Surgeons·2026
Same author

The current state of acute care surgery workforce and practice models: A joint statement by the American Association for the Surgery of Trauma, the American College of Surgeons Committee on Trauma, the Eastern Association for the Surgery of Trauma, and the Western Trauma Association.

The journal of trauma and acute care surgery·2026
Same journal

Diagnostic value of miR-126-5p in sepsis-induced acute kidney injury and its molecular mechanism via CASP3.

Shock (Augusta, Ga.)·2026
Same journal

Temporal changes of the von Willebrand factor-ADAMTS13 axis during the first 24 hours in major trauma patients with isolated brain injury and without brain injury: a prospective observational study.

Shock (Augusta, Ga.)·2026
Same journal

Epinephrine nebulization delays need for life-saving intervention following smoke inhalation in ovine model.

Shock (Augusta, Ga.)·2026
Same journal

Sodium-Glucose Cotransporter 2 Inhibitors as Discharge Medications in Survivors of Acute Myocardial Infarction Complicated by Cardiogenic Shock.

Shock (Augusta, Ga.)·2026
Same journal

Dynamic Temperature Modeling Predicts Mortality in Murine Sepsis.

Shock (Augusta, Ga.)·2026
Same journal

Changes of Intestinal Aquaporins after Experimental Polytrauma and Hemorrhagic Shock: Erratum.

Shock (Augusta, Ga.)·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

24.7K

PLASMA UTILIZATION EXACERBATES RENAL CORTEX INFLAMMATION IN A RODENT MODEL OF HEMORRHAGIC SHOCK AND RESUSCITATION.

William B Risinger1, Paul J Matheson1, Marisa E Franklin1

  • 1Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky.

Shock (Augusta, Ga.)
|February 18, 2025
PubMed
Summary
This summary is machine-generated.

Fresh frozen plasma (FFP) resuscitation in traumatic hemorrhagic shock did not improve kidney blood flow compared to lactated ringer's. However, FFP increased kidney size and exacerbated renal inflammation, suggesting complex effects on kidney microcirculation.

Keywords:
Hemorrhagic shockchemokineplasmarenal inflammationresuscitation

More Related Videos

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.1K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

1.2K

Related Experiment Videos

Last Updated: May 12, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

24.7K
Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.1K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

1.2K

Area of Science:

  • Trauma resuscitation
  • Renal physiology
  • Inflammation biology

Background:

  • Fresh frozen plasma (FFP) is standard for traumatic hemorrhagic shock, improving splanchnic and pulmonary circulation.
  • The effect of FFP on kidney circulation and inflammation is not well understood.
  • Hypothesis: FFP improves intrarenal blood flow and reduces inflammation compared to lactated ringer's.

Purpose of the Study:

  • To investigate the effects of FFP resuscitation on intrarenal hemodynamics and inflammation.
  • To compare FFP with lactated ringer's resuscitation in a model of hemorrhagic shock.

Main Methods:

  • Animal model of hemorrhagic shock randomized into four groups: baseline, shock alone, lactated ringer's, and FFP.
  • Doppler ultrasonography to assess renal blood flow and kidney diameter.
  • Multiplex immunoassays and immunohistochemistry to evaluate renal cytokine/chemokine signaling and leukocyte infiltration.

Main Results:

  • No significant difference in renal artery or parenchymal resistive index between FFP and lactated ringer's groups.
  • FFP resuscitation led to a significant increase in transverse kidney diameter.
  • Plasma administration increased renal cytokine/chemokine signaling and leukocyte infiltration compared to lactated ringer's.

Conclusions:

  • FFP resuscitation did not enhance macro-circulatory renal blood flow in this model.
  • Increased kidney diameter with FFP may suggest microcirculatory augmentation.
  • FFP resuscitation appears to worsen renal cortical inflammation post-hemorrhage, necessitating further investigation.