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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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[Clinical phenotyping of acute aortic dissection patients: a latent class analysis based on a multicenter

Abudunaibi Balati1, W H Wang2, X W He1

  • 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan 430030, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|February 18, 2025
PubMed

Insights

Latent class analysis identified two distinct clinical subtypes of acute aortic dissection (AAD). These subtypes exhibit different characteristics and responses to treatment, aiding in personalized patient care and prognosis.

Area of Science:

  • Cardiovascular Medicine
  • Medical Statistics
  • Clinical Research

Background:

  • Acute aortic dissection (AAD) is a life-threatening condition with varied clinical presentations.
  • Current classification systems may not fully capture the heterogeneity of AAD.
  • Understanding distinct patient subgroups is crucial for optimizing treatment and outcomes.

Purpose of the Study:

  • To identify and characterize clinical subtypes of acute aortic dissection (AAD) using latent class analysis.
  • To compare the clinical features and in-hospital mortality between identified AAD subtypes.
  • To explore differential treatment responses based on the identified subtypes.

Main Methods:

  • A multicenter retrospective cohort study involving 2,689 AAD patients.
  • Latent class analysis was employed to classify patients based on clinical and biological characteristics.
  • Model fitting evaluations determined the optimal number of latent classes.
  • Clinical data and in-hospital mortality were analyzed and compared across subtypes.

Main Results:

  • Latent class analysis identified two optimal subtypes of AAD.
  • Clinical subtype 2, compared to subtype 1, showed higher rates of female patients, older age, ascending aorta involvement, organ dysfunction, and inflammatory response.
  • Clinical subtype 2 had significantly higher in-hospital mortality, particularly among surgically treated patients.

Conclusions:

  • Latent class analysis successfully identified two distinct clinical subtypes of AAD.
  • These subtypes possess unique clinical profiles and differential responses to surgical intervention.
  • Findings support individualized clinical decision-making and prognostic assessment for AAD patients.

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