Bioconversion yields must account for all carbon: hidden biases from complex media
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1McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Trends in Biotechnology
|February 18, 2025
Abstract:
Yield ratio is a critical parameter for quantifying bioprocess conversion efficiency. However, unquantified carbon in complex media formulations complicates yield calculations. We highlight the biases introduced by improperly neglecting all carbon-containing molecules. We recommend that yields be reported by accounting for all carbon and that media formulations are always stated.
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