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Related Experiment Video

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Development and clinical validation of a novel platelet count-based nomogram for predicting microvascular invasion in

Wenjie Zheng1,2,3, Haoqi Chen1,3, Jianfeng Zhang1

  • 1Department of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.

Scientific Reports
|February 18, 2025
PubMed
Summary

This study developed a nomogram to predict the risk of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients before surgery. Key predictors include tumor size, BCLC stage, platelet count, AST, and AFP levels, offering a valuable clinical tool.

Keywords:
Hepatocellular carcinomaMicrovascular InvasionNomogramPlatelet

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Area of Science:

  • Hepatobiliary Surgery
  • Oncology
  • Diagnostic Imaging

Background:

  • Microvascular invasion (MVI) is a critical prognostic factor in hepatocellular carcinoma (HCC).
  • Accurate preoperative prediction of MVI is essential for optimal treatment planning and patient management.
  • Current methods for MVI detection often lack convenience or accuracy in the preoperative setting.

Purpose of the Study:

  • To develop and validate a user-friendly nomogram for predicting preoperative MVI in HCC patients.
  • To identify independent risk factors associated with MVI in HCC.

Main Methods:

  • Retrospective review of HCC patients who underwent surgical resection.
  • Univariate and multivariable logistic regression analyses to identify risk factors.
  • Construction and validation of a predictive nomogram using identified risk factors.

Main Results:

  • Tumor diameter (≥5 cm), BCLC stage, platelet count (>127.50 × 10^9/L), AST (>29.50 U/L), and AFP (>10.07 ng/ml) were significant predictors of MVI.
  • The nomogram achieved an AUC of 0.69 (95% CI: 0.64-0.73) for MVI prediction.
  • Calibration curves and decision curve analysis confirmed the nomogram's accuracy and clinical utility.

Conclusions:

  • A convenient nomogram effectively predicts preoperative MVI in HCC patients.
  • High platelet counts are strongly associated with MVI presence in HCC.
  • The developed nomogram demonstrates decent accuracy and clinical applicability for guiding surgical decisions.