Related Experiment Video
Updated: May 27, 2025
09:03
Extraction of Extracellular Vesicles from Whole Tissue
Published on: February 7, 2019
14.9K
On the road: extracellular vesicles in intercellular communication.
Silja Wessler1, Nicole Meisner-Kober2
1Department of Biosciences and Medical Biology, Center for Tumor Biology and Immunology (CTBI), Paris-Lodron University Salzburg, University of Salzburg, Salzburg, Austria. silja.wessler@plus.ac.at.
Cell Communication and Signaling : CCS
|February 19, 2025
Summary
Cells release extracellular vesicles (EVs) for homeostasis and communication. These nanovesicles are key to intercellular signaling in health and disease, with growing biomedical applications.
Area of Science:
- Cell Biology
- Biochemistry
- Physiology
Background:
- Cells release diverse extracellular vesicles (EVs) for homeostasis and intercellular communication.
- EVs are nanosized vesicles generated from endomembranes or plasma membrane.
- Macromolecular cargo is loaded into EVs via controlled molecular sorting.
Discussion:
- EVs mediate intercellular communication within tissues, between organs, and across organisms.
- Research on fundamental EV biology and biomedical applications has intensified over the last 15 years.
- EVs are increasingly recognized as essential mediators in health and disease.
Key Insights:
- EVs play crucial roles in orchestrating intercellular communication.
- Controlled molecular sorting ensures specific cargo loading into EVs.
- EVs impact recipient cells locally and systemically.
Outlook:
- Advances in EV biogenesis, intercellular communication, and technical applications are highlighted.
- The potential for biomedical applications of EVs is a significant area of ongoing research.
- This thematic series presents new findings on EVs for Cell Communication and Signaling.
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