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Updated: May 27, 2025
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Hemoglobin phenotypes of children attending pediatric clinics in Lomé, Togo, 2022
Yao Rodion Konu1,2, Fiali Ayawa Lack3, Oumarou I Wone Adama4
1Centre Africain de Recherche en Epidémiologie et en Santé Publique (CARESP), Lomé, Togo. rodionko@yahoo.fr.
Insights
This study in Togo found a 6.0% frequency of sickle cell disease in children attending clinics. Increased community education on hemoglobin phenotype and premarital screening are crucial to reduce this burden.
Area of Science:
- Pediatrics
- Hematology
- Public Health
Background:
- Sickle cell disease (SCD) is a significant global health concern.
- Understanding the prevalence of SCD in specific pediatric populations is essential for targeted interventions.
- Limited recent data exists for Togo.
Purpose of the Study:
- To determine the frequency of sickle cell disease (SCD) among children in pediatric clinics.
- To provide current epidemiological data for Lome, Togo.
Main Methods:
- Cross-sectional study conducted in 2022.
- Inclusion of 317 children attending pediatric clinics at Sylvanus Olympio University Hospital.
- Data collected on demographics and hemoglobin phenotypes.
Main Results:
- Nineteen children (6.0%) were diagnosed with sickle cell disease (SCD).
- 15.6% of children had sickle cell trait (HbAS).
- Parental knowledge of hemoglobin phenotype was low (7.3%).
Conclusions:
- A high frequency of sickle cell disease (SCD) was observed in the studied pediatric population.
- There is a critical need for enhanced community education regarding hemoglobin phenotypes.
- Premarital screening is vital to mitigate the prevalence of SCD in Togo.
Objective:
To provide an up-to-date data, we aim to estimate the frequency of sickle cell disease among children in the pediatric clinics of the Sylvanus Olympio University Hospital, Lome, Togo, in 2022.
Results:
A total of 317 children with a median age of 8 years (Interquartile range: 4-12) were included. Both parents knew their Hb phenotype in 7.3% of cases. Nineteen children had sickle cell disease (6.0%) and about 15.6% of the children had sickle cell trait AS. This study found a high frequency of children with sickle cell disease seen in pediatric clinics. We therefore emphasize the need for continued education to improve knowledge of the hemoglobin phenotype at community level and the importance of premarital screening to reduce this burden in the country.
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