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Association between systemic inflammatory response index and glaucoma incidence from 2005 to 2008
Xiang Li1, Yi Qing Sun2, Xiao Dan Zhong3
1Eye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China.
Frontiers in Medicine
|February 19, 2025
Summary
Elevated Systemic Inflammatory Response Index (SIRI) levels are linked to a higher prevalence of glaucoma. This finding suggests systemic inflammation may play a role in glaucoma development, potentially aiding early detection.
Area of Science:
- Ophthalmology and systemic disease research.
- Investigating the link between inflammatory markers and ocular conditions.
Background:
- Glaucoma is a leading cause of irreversible blindness worldwide.
- Systemic inflammation is increasingly recognized as a contributing factor in various chronic diseases.
- The Systemic Inflammatory Response Index (SIRI) is a composite marker of inflammation.
Purpose of the Study:
- To examine the association between the Systemic Inflammatory Response Index (SIRI) and glaucoma prevalence.
- To explore the potential of SIRI as a biomarker for glaucoma risk.
Main Methods:
- Cross-sectional analysis of 4,514 participants from the 2005-2008 National Health and Nutrition Examination Survey (NHANES).
- Calculation of SIRI and other inflammatory indices (SII, PLR, NLR) from blood samples.
- Logistic regression models used to assess the relationship between inflammatory indices and glaucoma, adjusting for covariates.
Main Results:
- A significant positive association was observed between elevated log2SIRI levels and glaucoma prevalence (OR 1.24, 95% CI 1.07-1.44).
- The highest quartile of log2SIRI (Q4) showed a significant association with glaucoma occurrence (OR 1.62, 95% CI 1.12-2.34).
- The area under the receiver operator characteristic curve (AUC) supported the predictive value of SIRI in Model 3 (AUC=0.674).
Conclusions:
- Elevated SIRI levels are significantly associated with a higher prevalence of glaucoma.
- Systemic inflammation, as indicated by SIRI, may contribute to glaucoma pathogenesis.
- SIRI could potentially serve as a valuable biomarker for early glaucoma detection and risk stratification.
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