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Prognostic value of systemic immune-inflammation index for patients undergoing radical prostatectomy: a systematic

Zhan Chen¹, Yao Zhang¹, Wei Chen²

¹Department of Urology, Cixilntegrated Traditional Chinese and Western Medicine Medical, Ningbo, Zhejiang, China.

Frontiers in Immunology

|February 19, 2025

Summary

This summary is machine-generated.

The systemic immune-inflammation index (SII) is linked to poorer survival outcomes in prostate cancer patients after radical prostatectomy. However, the evidence quality is low, necessitating further research for definitive conclusions.

Keywords:

SII meta-analysis prostate cancer prostatectomy systemic immune-inflammation index

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Area of Science:

Oncology
Immunology
Prognostic Biomarkers

Background:

The prognostic significance of the systemic immune-inflammation index (SII) in prostate cancer (PCa) patients undergoing various treatments is not well-established.
Radical prostatectomy (RP) is a primary treatment for localized PCa, and understanding prognostic factors is crucial for patient management.

Purpose of the Study:

To investigate the prognostic value of the systemic immune-inflammation index (SII) in patients with prostate cancer (PCa) who have undergone radical prostatectomy (RP).
To evaluate the association between SII and survival outcomes, including overall survival (OS), biochemical recurrence-free survival (BFS), and cancer-specific survival (CSS).

Main Methods:

A systematic literature search was conducted across multiple databases (PubMed, Embase, Web of Science, Cochrane, Wanfang, CNKI) up to May 2024.
Eight studies involving 8,267 patients were included, with study quality assessed using the Newcastle-Ottawa Scale.
Pooled analyses, Egger's test, sensitivity analysis, and GRADE assessment were performed to evaluate the association between SII and survival outcomes.

Main Results:

Higher SII levels were significantly associated with shorter overall survival (OS) (HR: 1.89), biochemical recurrence-free survival (BFS) (HR: 1.55), and cancer-specific survival (CSS) (HR: 3.63) in PCa patients post-RP.
The evidence quality for OS and CSS was rated as very low due to significant heterogeneity and imprecision.
Evidence for BFS was rated as low-quality, with no serious risk observed.

Conclusions:

Elevated SII is associated with reduced survival outcomes (OS, BFS, CSS) in prostate cancer patients following radical prostatectomy.
The current evidence supporting these associations is of low to very low quality, highlighting the need for high-quality prospective studies.