Differential contributions of CA3 and entorhinal cortex inputs to ripple patterns in the hippocampus

Hippocampal ripples project reactivated memories to many brain areas, and recently it has been proposed that different types of ripples exist whose information content is influenced by different regions. Utilizing a threshold-based approach, our study differentiated distinct ripple types in rats, clarifying the contributions of intra-hippocampal (CA3) and cortical (mEC) regions to these events. The findings reveal that different ripple types differ in the relative contributions of both regions to their generation, and interestingly cannabidiol ingestion primarily influences the CA3's input to the CA1, resulting in an increased occurrence of short ripples predominantly induced by cortical (mEC) activity and a corresponding decrease in long, intra-hippocampal sharp-wave ripples. This study highlights the critical interplay between the CA3 and entorhinal cortex dynamics in shaping the characteristics of hippocampal ripples.