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Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors

  • 0Department of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in Oncology +

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February 19, 2025

|

February 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Persistent human papillomavirus (HPV) infection after surgery is a key risk factor for recurrence in early-stage cervical cancer. Smoking and abnormal vaginal microbiota also influence persistent HPV infection post-surgery.

Area Of Science

  • Gynecology
  • Oncology
  • Infectious Diseases

Background

  • Cervical cancer remains a significant global health concern.
  • Surgical treatment is standard for early-stage disease (FIGO stages IA1-IIA1).
  • Understanding postoperative recurrence factors is crucial for improving patient outcomes.

Purpose Of The Study

  • To identify factors influencing recurrence after surgery for early-stage cervical cancer.
  • To investigate the link between human papillomavirus (HPV) infection and postoperative recurrence.
  • To determine risk factors for persistent HPV infection following surgical treatment.

Main Methods

  • Retrospective analysis of 242 patients with early-stage cervical cancer (FIGO stages IA1-IIA1).
  • Surgical treatment data collected between 2015-2022.
  • Cox regression analysis used to assess HPV infection persistence and recurrence risk.

Main Results

  • HPV clearance rate was 88.11% within 12 months post-surgery.
  • Persistent HPV infection occurred in 7.9% of patients.
  • Persistent postoperative HPV infection (OR 1.72) was an independent risk factor for recurrence. Smoking (OR 7.49) and abnormal vaginal microbiota (OR 0.663) were associated with persistent HPV infection.

Conclusions

  • Persistent HPV infection post-surgery is an independent risk factor for recurrence in early-stage cervical cancer.
  • Surgical approach, abnormal vaginal microbiota, and smoking are associated with persistent HPV infection.
  • Targeting these factors may help reduce recurrence rates.

Keywords:

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