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Reversing regulatory safeguards: Targeting the ATR pathway to overcome PARP inhibitor resistance

Xixi Lin1,2, Ye Qiu1,2, Aashish Soni1,2

  • 1Department of Radiation Therapy, Division of Experimental Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Molecular Therapy. Oncology
|February 19, 2025
PubMed

Keywords:
ATR inhibitorsDNA double-stranded breaksMT: Regular IssuePARP inhibitorscancercell-cycle checkpointchemotherapyhomologous recombinationreplication fork

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