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Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions

  • 0Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, China.
Materials Today. Bio +

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February 19, 2025

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February 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study introduces GALA, a novel ionic liquid, to enhance the transdermal delivery of hexapeptide-9 for effective wrinkle removal. The combination offers a safe and potent solution for anti-aging treatments.

Area Of Science

  • Biomaterials Science
  • Dermatology
  • Drug Delivery

Background

  • Facial wrinkles, both static and dynamic, necessitate varied treatments.
  • Peptides are effective anti-aging agents but suffer from poor skin penetration.
  • Existing treatments often fail to address both wrinkle types simultaneously.

Purpose Of The Study

  • To develop a novel transdermal delivery system for hexapeptide-9 using a neuro-soothing ionic liquid, GALA.
  • To evaluate the efficacy of GALA in enhancing hexapeptide-9 delivery for simultaneous static and dynamic wrinkle treatment.
  • To ensure high biosafety through the use of endogenous components.

Main Methods

  • Preparation of GALA from gamma-aminobutyric acid (GABA) and lactic acid (LA).
  • In vitro transdermal, cellular, animal, and clinical experiments to assess GALA's performance.
  • Analysis of skin barrier alteration, permeation, retention, and cellular pathways activated by hexapeptide-9.

Main Results

  • GALA significantly enhanced hexapeptide-9 transdermal permeation (4.79-fold) and subcutaneous retention (7.89-fold) after 12 hours.
  • GALA demonstrated high biosafety due to the endogenous nature of its components.
  • Hexapeptide-9, delivered by GALA, activated the PPAR signaling pathway, reducing oxidative stress, inflammation, and collagen degradation.

Conclusions

  • The GALA/hexapeptide-9 system is a safe and effective enhancer for transdermal delivery, targeting both static and dynamic wrinkles.
  • This novel approach shows significant potential for advanced anti-wrinkle and anti-aging therapies.
  • Further research into bioactive ionic liquids as transdermal enhancers is warranted for clinical applications.

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