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Peptic perforation due to Candida spp
Silvia Fernández Noël1, Julia Gutiérrez de Prado2, Óscar Caso Maestro2
1Cirugía General y del Aparato Digestivo, Hospital Universitario 12 de Octubre, España.
Abstract:
The incidence of peptic perforation has not decreased despite the successful management of Helicobacter pylori (HP), suggesting other mechanisms are involved in the pathological process. Our findings support the relevance of Candida spp. in these types of perforations. These findings provide insight into the management of peptic perforations complicated by fungal infections and highlight the importance of routinely performing peritoneal culture and biopsies in these patients. We propose that Candida coinfection be considered an independent risk factor in the mortality of patients with peritonitis, as shown by other studies.
Insights
Peptic perforations remain common, even with Helicobacter pylori treatment. Candida species are relevant in these perforations, suggesting fungal coinfection may be an independent risk factor for mortality in peritonitis.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Surgical Pathology
Background:
- Peptic perforation incidence persists despite effective Helicobacter pylori (HP) management.
- This suggests alternative or additional pathological mechanisms contribute to peptic perforations.
- The role of fungal pathogens, specifically Candida species, in these cases requires further investigation.
Purpose of the Study:
- To investigate the involvement of Candida species in peptic perforations.
- To explore the clinical significance of fungal coinfection in peptic perforations.
- To determine if Candida coinfection is an independent risk factor for mortality in peritonitis.
Main Methods:
- Analysis of patient data and clinical outcomes for peptic perforations.
- Microbiological analysis, including peritoneal cultures and biopsies, to identify Candida spp.
- Statistical analysis to assess the correlation between Candida coinfection and mortality.
Main Results:
- Findings support the significant relevance of Candida species in peptic perforations.
- Routine peritoneal cultures and biopsies are highlighted as important diagnostic tools.
- Candida coinfection is proposed as an independent risk factor for mortality in peritonitis.
Conclusions:
- Candida species play a role in peptic perforations, independent of Helicobacter pylori.
- Routine microbiological assessment of peritoneal fluid and tissue is crucial for managing these complex cases.
- Considering Candida coinfection as an independent mortality risk factor is essential for patient management and prognosis.
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