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Magnetic Resonance-Guided Focused Ultrasound Treatment for Essential Tremor: A Single-Center Experience
Victor S Hvingelby1,2,3, Pernille Kjeldsen2,3, Bo Bergholt1
1Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark.
Background:
Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging-guided focused ultrasound (MRgFUS) has emerged as second-line therapy.
Objective:
The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark.
Methods:
Data were entered in a quality assurance database at baseline and 3, 6, and 12 months. Clinician- and patient-rated treatment efficacy was evaluated using the Fahn-Marin-Tolosa (FMT) scale and the Patient Global Impression of Change.
Results:
A total of 108 persons have currently been treated. Tremor improved by a total mean 6.39 points (95% confidence interval [CI]: 5.01;7.76, P < 0.00001) and 9.63 points (95% CI: 7.60;11.66, P < 0.00001), 10.42 (95% CI: 9.06;11.79, P < 0.00001), and 26.45 (95% CI: 22.46;30.43, P < 0.00001) for FMT parts A, B, and C, respectively, at 3 months. Side effects occurred in 65.7% of patients at 3 months and 33.7% at 12 months.
Conclusion:
Our findings are in line with existing evidence. Questions regarding persistence of gait- and balance-related side effects remain.
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