Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Effects of Radiation

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessment of the mechanical performance of a novel CT-linac treatment couch.

Frontiers in oncology·2026

Same author

High-risk EBV promotes immune evasion in nasopharyngeal carcinoma by upregulating HLA-DP via the encoded BALF2-HR variant.

Nature communications·2026

Same author

The cGAS-STING pathway in cancer: friend or foe.

Cell death & disease·2026

Same author

Pseudouridine synthases upregulate 5'-tRF-Lys to inhibit YPEL3 and drive malignant progression in nasopharyngeal carcinoma.

Cellular & molecular biology letters·2026

Same author

Developing an automatic decision-assistance tool to choose proton/photon radiotherapy for patients with prostate cancer.

Journal of applied clinical medical physics·2026

Same author

CARE-Net: Causal-aware risk embedding for venous thromboembolism prediction in orthopedic inpatients.

Thrombosis research·2026

Search research articles

Related Experiment Video

Updated: Jun 13, 2025

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Dose rate correction of a diode array for universal wedge field dosimetric verification.

Linyi Shen¹, Mengyang Li¹, Guiyuan Li¹

¹National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal of Applied Clinical Medical Physics

|February 19, 2025

Summary

MapCHECK 3 (MC3) measurements of universal wedge fields show inaccuracies due to dose rate dependence. A proposed correction strategy significantly improves MC3 measurement accuracy for these complex fields.

Keywords:

MapCHECK 3 dose rate correction dose verification universal wedge field

More Related Videos

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

Related Experiment Videos

Last Updated: Jun 13, 2025

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

Area of Science:

Medical Physics
Radiation Oncology
Dosimetry

Background:

The MapCHECK 3 (MC3) is a detector used for dose verification in radiation therapy.
Universal wedge fields present unique challenges for accurate dose measurement due to their inherent properties.
Type 4 diodes in MC3 exhibit dose rate dependence, potentially affecting measurement accuracy.

Purpose of the Study:

To evaluate the performance of the MapCHECK 3 (MC3) system for measuring universal wedge fields.
To develop and validate a dose rate correction strategy to enhance MC3 measurement accuracy in these fields.

Main Methods:

Universal wedge fields were measured at various depths, angles, and field sizes using MC3.
A software-based correction program was developed to adjust measurements based on instantaneous dose rate (IDR).
MC3 measurements (with and without correction) were compared against ion chamber and treatment planning system (TPS) data.

Main Results:

Without correction, MC3 measurements of universal wedge fields showed errors up to -2.4% for central axis dose and up to -2.9% for other factors.
Off-axis dose errors were larger on the wedge's heel side compared to the toe side.
After implementing the dose rate correction, central axis dose deviations were reduced to within ±1.5%, and the average gamma pass rate exceeded 99.5%.

Conclusions:

Standard MC3 measurement protocols for open fields are inadequate for universal wedge fields due to diode dose rate dependence.
The proposed instantaneous dose rate (IDR) correction strategy is effective and practical for improving MC3 accuracy in universal wedge field measurements.