Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Geriatric depression: a guide to successful therapy.

L W Lazarus, J M Davis, M W Dysken

    Geriatrics
    |June 1, 1985
    PubMed
    Summary

    Tricyclic secondary amines are effective for treating depression in elderly patients, offering fewer side effects than tertiary amines. Differentiating depression from dementia in older adults can be challenging due to overlapping symptoms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of ethanol administration and withdrawal on serotonin receptor subtypes and receptor-mediated phosphoinositide hydrolysis in rat brain.

    Alcoholism, clinical and experimental research·1992
    Same author

    Effects of brief, heavy exertion on circulating lymphocyte subpopulations and proliferative response.

    Medicine and science in sports and exercise·1992
    Same author

    Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients.

    Schizophrenia research·1992
    Same author

    Monoamine oxidase and cortisol response in depression and schizophrenia.

    Psychiatry research·1992
    Same author

    Platelet monoamine oxidase in schizophrenia: a meta-analysis.

    Schizophrenia research·1992
    Same author

    Effect of electroconvulsive shock on 5-HT2 and alpha 1-adrenoceptors and phosphoinositide signalling system in rat brain.

    European journal of pharmacology·1992

    Area of Science:

    • Geriatric Psychiatry
    • Neuroscience
    • Pharmacology

    Background:

    • Elderly patients with apathy and withdrawal may present with depression.
    • Depression onset is typically sudden, contrasting with the gradual onset of degenerative dementias like Alzheimer's disease.
    • Concomitant depression in demented elderly patients complicates clinical assessment.

    Purpose of the Study:

    • To compare the efficacy of tricyclic secondary amines versus tertiary amines in treating depression in elderly patients.
    • To highlight the differential diagnostic features between depression and dementia in the elderly.
    • To underscore the challenges in assessing depression in elderly patients with co-existing dementia.

    Main Methods:

    • Clinical assessment of elderly patients presenting with apathy and withdrawal.
    • Pharmacological comparison of tricyclic secondary amines (e.g., desipramine, nortriptyline) and tricyclic tertiary amines.
    • Differential diagnosis based on symptom onset and progression.

    Main Results:

    • Tricyclic secondary amines demonstrate comparable efficacy to tricyclic tertiary amines in treating depression.
    • Tricyclic secondary amines are associated with reduced anticholinergic and sedating side effects.
    • Distinguishing between depression and dementia requires careful consideration of symptom onset and progression.

    Conclusions:

    • Tricyclic secondary amines are a viable and potentially preferable treatment option for depression in the elderly due to their side effect profile.
    • Accurate diagnosis in elderly patients with potential co-existing depression and dementia is crucial for effective management.
    • Further research may be needed to refine diagnostic criteria and treatment strategies for this complex patient population.

    Related Experiment Videos