Causal relationship between gut microbiota and androgenetic alopecia: A Mendelian randomization study

Recent studies have found a strong correlation between gut microbiota and the risk of skin diseases and proposed a "gut-skin axis." Androgenetic alopecia (AGA) is the most common type of alopecia, and androgen plays an important role in its pathogenesis. It has been found that the gut microbiome is closely related to androgens; however, whether this relationship is causal or merely coincidental remains uncertain. To address this issue, Mendelian randomization (MR) analysis was performed to explore the association between gut microbiota and AGA. Genome-wide association studies (GWAS) have compiled summary statistics of the gut microbiota, including 211 taxa (131 genera, 35 families, 20 orders, 16 classes, and 9 phyla), with data from MiBioGen's comprehensive study. We collected genetic associations with AGA from the IEU OpenGWAS project. We performed MR Analyses to assess the causal relationship between the genetically predicted gut microbiota and AGA. In order to verify the reliability of the findings, we systematically performed sensitivity analyses and heterogeneity tests and performed a heterogeneity test. MR Analysis provides important evidence for the causal relationship between genetically predicted gut microbiota and AGA. Lachnospiraceae UCG008 (OR = 0.939, 95%CI 0.175-0.775, P < .01), Oxalobacte (OR = 0.932, 95%CI 0.896-0.969, P < .01) would reduce the risk of AGA. Eubacterium rectale group (OR = 1.102, 95%CI 1.025-1.186, P < .01), Roseburia (OR = 1.183, 95%CI 1.048-1.336, P < .01) would increase the risk of AGA. Further sensitivity and heterogeneity analyses confirmed the robustness of these results. The results of this study indicate that there is a potential genetic susceptibility between gut microbiota and AGA, and screen out protective and risk factors. These results provide a theoretical basis for the prevention and treatment of AGA by regulating gut microbiota.