Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

2.6K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.6K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

21.8K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
21.8K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K
Stem Cell Culture01:17

Stem Cell Culture

5.1K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.1K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.2K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous Medial Patellofemoral Ligament and Medial Quadriceps Tendon-Femoral Ligament Reconstructions Using an Artificial Ligament for Lateral Patella Instability.

Arthroscopy techniques·2022
Same author

Postoperative Residual Coronal Decompensation Inhibits Self-image Improvement in Adolescent Patients with Idiopathic Scoliosis.

Asian spine journal·2022
Same author

Verification of efficacy and safety of ibandronate or denosumab for postmenopausal osteoporosis after 12-month treatment with romosozumab as sequential therapy: The prospective VICTOR study.

Bone·2022
Same author

Isolated cardiac sarcoidosis associated with coronary vasomotion abnormalities: a case report.

European heart journal. Case reports·2022
Same author

Diagnostic Criteria for Moyamoya Disease - 2021 Revised Version.

Neurologia medico-chirurgica·2022
Same author

Impact of statins in patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association.

Journal of cardiology·2022
Same journal

Dialysis bioreactor enables high-density, serum-free expansion of dental pulp-derived mesenchymal stromal cells with enhanced secretome.

Cytotherapy·2026
Same journal

Beyond the synapses: should we anticipate neurotransmitter signaling when manufacturing CAR-T cells for brain tumors?

Cytotherapy·2026
Same journal

Curative treatment for severe sickle cell disease: allogeneic hematopoietic cell transplant or gene therapy.

Cytotherapy·2026
Same journal

Manufacturing strategies for prolonged CAR-T cell persistence.

Cytotherapy·2026
Same journal

Overcoming five main challenges to targeting hematologic malignancies.

Cytotherapy·2026
Same journal

Mesenchymal stromal cell-based therapy in the COVID-19 pandemic: results from an academic phase I/II double-blind, randomized, placebo-controlled clinical trial and reflections for the field.

Cytotherapy·2026
See all related articles

Related Experiment Video

Updated: May 27, 2025

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

14.2K

iPSC-based cell replacement therapy: from basic research to clinical application.

Jun Takahashi1

  • 1Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

Cytotherapy
|February 19, 2025
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) are advancing regenerative medicine for Parkinson's disease. iPSC-derived neurons show promise for cell replacement therapy, with clinical trials on the horizon.

Keywords:
cell replacement therapyclinical trialinduced pluripotent stem cellspreclinical study

More Related Videos

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

7.1K
Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
10:03

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes

Published on: November 11, 2016

9.7K

Related Experiment Videos

Last Updated: May 27, 2025

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

14.2K
Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

7.1K
Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
10:03

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes

Published on: November 11, 2016

9.7K

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Neuroscience

Background:

  • Induced pluripotent stem cell (iPSC) technology has significantly impacted regenerative medicine, offering new avenues for disease modeling, drug discovery, and cell replacement therapies.
  • Cell replacement therapy, particularly using iPSC-derived cells, is a key focus for treating degenerative diseases.
  • The Replacement Effect mechanism is vital for achieving long-term tissue regeneration and functional recovery.

Purpose of the Study:

  • To review the progress of iPSC-based regenerative medicine, with a specific emphasis on cell replacement therapy.
  • To explore the application of iPSC technology in Parkinson's disease, including the induction of dopaminergic neurons.
  • To highlight the importance of interdisciplinary collaboration for the successful clinical translation of iPSC therapies.

Main Methods:

  • Review of existing literature on iPSC technology and its applications in regenerative medicine.
  • Focus on studies detailing the induction of midbrain dopaminergic neurons from iPSCs.
  • Analysis of animal studies demonstrating the safety and integration of iPSC-derived cells.

Main Results:

  • iPSC technology has enabled significant progress in disease modeling and drug discovery.
  • Successful induction of midbrain dopaminergic neurons from iPSCs has been achieved, with precise signaling crucial for safety and efficacy.
  • Animal studies have confirmed the integration and safety of these cells, supporting progression to clinical trials.

Conclusions:

  • iPSC-based cell replacement therapy holds substantial promise for treating neurodegenerative diseases like Parkinson's.
  • Strategic collaboration among regulatory bodies, researchers, clinicians, and industry is essential for clinical success.
  • Continued advancements in iPSC technology are expected to broaden therapeutic applications and enhance patient outcomes.