Related Experiment Video
Updated: May 27, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Respiratory Viral Infection Unmasking Congenital Heart Disease
Insights
Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital heart defect. Early diagnosis and surgical correction are critical to prevent high infant mortality rates.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Disease
- Medical Imaging
Background:
- Congenital heart disease impacts approximately 1% of newborns annually.
- Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare condition, accounting for 0.25%-0.50% of congenital cardiac diseases.
- Untreated ALCAPA has a mortality rate as high as 90% in infants.
Purpose of the Study:
- To report a case of ALCAPA in an infant presenting with respiratory illness.
- To highlight the diagnostic utility of echocardiography and CT angiography in ALCAPA.
- To emphasize the importance of timely surgical intervention and post-operative care.
Main Methods:
- Case report of a 4-month-old infant.
- Diagnostic imaging included chest radiography, echocardiography, and gated computed tomography angiography (CTA).
- Surgical correction and post-operative circulatory support were performed.
Main Results:
- The infant presented with cardiomegaly and severe left ventricular dysfunction.
- Echocardiography suggested ALCAPA, which was confirmed by CTA.
- Successful surgical correction and recovery with circulatory support were achieved.
Conclusions:
- ALCAPA is a critical congenital heart defect requiring prompt diagnosis and management.
- Multimodality imaging plays a vital role in diagnosing ALCAPA.
- Urgent surgical repair and appropriate post-operative care are essential for favorable outcomes in ALCAPA patients.
Abstract:
Congenital heart disease affects nearly 1% of all live births or 40,000 infants each year. Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital heart defect that constitutes 0.25% to 0.50% of all congenital cardiac diseases. If left untreated, infant mortality is as high as 90%. The following is a case report of a 4-month-old infant presenting with respiratory viral illness and a chest radiograph demonstrating cardiomegaly. Echocardiography revealed possible ALCAPA with severe left ventricular (LV) dysfunction. The diagnosis was confirmed using gated computed tomography angiography (CTA). The patient required urgent surgical correction and post-operative circulatory support for myocardial rest in the setting of severe left ventricular dysfunction.
Related Concept Videos
Common Respiratory Disorders
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Acute Respiratory Failure-III
Pulmonary Cycle: Exhalation

