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Related Experiment Video

Updated: May 27, 2025

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
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The association between the number of chronic conditions and treatment of patients who are at high risk for future

Anum Ali1, Ella Huszti2,3, Shahryar Noordin4

  • 1Institute of Health Policy, Management and Evaluation, University of Toronto, 4th Floor- 155 College Street, Toronto, ON, M5T 3M6, Canada. Anum.asifhakimali@mail.utoronto.ca.

Archives of Osteoporosis
|February 19, 2025
PubMed
Summary
This summary is machine-generated.

Patients with two chronic conditions were more likely to receive and initiate fracture prevention medication. However, those with three or more conditions faced lower prescription and initiation rates, indicating a need for tailored care.

Keywords:
Fracture Liaison ServiceFracture Screening and Prevention Program (FSPP)Fragility fracturesMultiple chronic conditionsTreatment

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Area of Science:

  • Gerontology
  • Pharmacology
  • Public Health

Background:

  • High-risk patients often have multiple chronic conditions, complicating fracture prevention.
  • The Fracture Screening and Prevention Program (FSPP) aims to identify and manage patients at risk of fractures.

Purpose of the Study:

  • To examine how the number of chronic conditions affects medication prescription and initiation in high-risk fracture patients.
  • To identify potential disparities in treatment outcomes based on comorbidity burden.

Main Methods:

  • Retrospective cohort study of 11,245 high-risk patients in the FSPP (June 2017-June 2022).
  • Patients categorized by number of chronic conditions: 0, 1, 2, or ≥3.
  • Multivariable logistic regression analyzed medication prescription and initiation rates.

Main Results:

  • Patients with two chronic conditions had higher odds of medication prescription (26%) and initiation (57%) versus those with none.
  • No significant differences in prescription/initiation for patients with 1 or ≥3 conditions compared to none.
  • Patients with ≥3 conditions showed 25-30% lower odds of prescription and initiation compared to those with two conditions.

Conclusions:

  • Having two chronic conditions was associated with better medication adherence in a fracture prevention program.
  • A high comorbidity burden (≥3 conditions) may lead to inequities in fracture prevention treatment.
  • Tailored interventions are crucial to optimize secondary fracture prevention for patients with multiple chronic conditions.