Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

3.4K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
3.4K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double-stage insect recognition model based on synergistic localization of key parts.

Frontiers in plant science·2026
Same author

Zanubrutinib, Lenalidomide, and Rituximab Demonstrate Efficacy in Relapsed/Refractory Central Nervous System Lymphoma: A Single - Center Retrospective Study.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2026
Same author

Mouse Oocyte In Vitro Maturation, Fertilization, and Culture of Preimplantation Embryos.

Journal of visualized experiments : JoVE·2026
Same author

Children consider what others did not know as well as what they could not do when judging their actions.

Developmental psychology·2026
Same author

Characteristics and Prognostic Implications in Newly Diagnosed KMT2Ar AML: A Multicenter Study of the ECLA Group.

American journal of hematology·2026
Same author

MSDDG: Multi-scale dual-discriminator GAN for point cloud completion of plant.

Plant phenomics (Washington, D.C.)·2026
Same journal

RNA regulation in plants.

Science China. Life sciences·2026
Same journal

Translating genetic testing into fertility care.

Science China. Life sciences·2026
Same journal

A newly identified palmitoylation-related molecular signature acts as predictor and possible therapeutic target of atherosclerosis.

Science China. Life sciences·2026
Same journal

A case study of proteomics-guided personalized targeted therapy.

Science China. Life sciences·2026
Same journal

Time-series dynamics and biocontrol potential of postharvest bacteria in litchi microbiota.

Science China. Life sciences·2026
Same journal

How NSUN2 reshapes tRNA for m<sup>5</sup>C modification.

Science China. Life sciences·2026
See all related articles

Related Experiment Video

Updated: May 27, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

6.3K

Stem cell-based embryo models: a tool to study early human development.

Baojiang Wu1,2, Jitesh Neupane3, Yang Zhou1,2

  • 1The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, 010020, China.

Science China. Life Sciences
|February 19, 2025
PubMed
Summary
This summary is machine-generated.

Stem cell-based embryo models (SCBEM) offer a novel way to study early mammalian development. These models mimic natural embryos, aiding research into human embryonic development and totipotency.

Keywords:
blastoidembryo modelgastruloidprimordial germ cellstem cell

More Related Videos

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
05:13

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

711
Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.2K

Related Experiment Videos

Last Updated: May 27, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

6.3K
Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
05:13

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

711
Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.2K

Area of Science:

  • Developmental Biology
  • Stem Cell Research
  • Reproductive Medicine

Background:

  • Understanding mammalian fertilized egg totipotency and development is crucial.
  • Studying human embryonic development in vitro presents significant challenges.
  • The regulatory mechanisms of early human development are not fully understood.

Purpose of the Study:

  • To review and compare mouse and human stem cell-based embryo models (SCBEM).
  • To assess the capability of SCBEM in mimicking natural embryos.
  • To provide a perspective on future applications of SCBEM in developmental biology.

Main Methods:

  • Comparative review of existing literature on mouse and human SCBEM.
  • Analysis of morphological and transcriptional similarities between SCBEM and natural embryos.
  • Discussion of the potential of SCBEM for studying pre- and post-implantation development.

Main Results:

  • SCBEM have been successfully generated for both mouse and human embryos.
  • These models exhibit similarities to natural embryos morphologically and transcriptionally.
  • SCBEM provide a valuable tool for investigating key developmental events.

Conclusions:

  • Stem cell-based embryo models are powerful tools for studying early mammalian development.
  • SCBEM offer a promising avenue to overcome limitations in studying human embryogenesis.
  • Further research with SCBEM can illuminate fundamental questions in developmental biology and regenerative medicine.