[Antibiotic Resistance: Threats and Search for Solution]

Antibiotic and, more broadly, antimicrobial resistance is a naturally occurring biological phenomenon and a major public health problem. Mass emergence of drug-resistant bacterial strains was first observed in the mid-20th century. Since then, cases of resistance have been reported worldwide, and multidrug resistance has been increasingly reported over the past two decades. Overuse of antibacterial agents and their release into the environment contribute to the development of bacterial resistance. Unfortunately, a search and design of new effective antibiotics are declining, while it is necessary to intensify such studies and to search for alternative methods to treat infectious diseases.