Interaction between polygenic risk score and reproductive factors in relation to lung cancer risk among Singaporean Chinese women
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View abstract on PubMed
Summary
This summary is machine-generated.Women who had hysterectomy or oophorectomy showed increased lung cancer risk. Genetic variants did not significantly modify this association, suggesting reproductive surgery history is a key risk factor for lung cancer.
Area Of Science
- Reproductive health and oncology
- Cancer epidemiology
- Genetics and cancer risk
Background
- Reproductive factors influence female hormone levels and may affect lung cancer risk.
- The role of genetic variants in modifying this association is not well understood.
Purpose Of The Study
- To investigate the association between reproductive factors and lung cancer risk in women.
- To evaluate whether genetic variants modify the relationship between reproductive factors and lung cancer risk.
Main Methods
- An age-matched case-control study involving 2910 female participants (1455 cases, 1455 controls).
- Logistic regression was used to estimate odds ratios (ORs) for reproductive factors and lung cancer.
- A polygenic risk score (PRS) was calculated to assess gene-environment interactions.
Main Results
- Hysterectomy (OR=1.41) and oophorectomy (OR=1.52) were associated with increased lung cancer risk.
- A lung cancer polygenic risk score (PRS) showed a linear association with lung cancer risk (Ptrend < 0.001).
- A borderline non-significant interaction was found between hormone use and PRS (Pinteraction-FDR = 0.05).
Conclusions
- History of hysterectomy or oophorectomy increases lung cancer risk, necessitating targeted prevention.
- No significant effect modification by the lung cancer PRS was observed for reproductive factors.
- Larger prospective studies are needed to confirm these findings.
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