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ProstAtlasDiff: Prostate cancer detection on MRI using Diffusion Probabilistic Models guided by population spatial
Cynthia Xinran Li1, Indrani Bhattacharya2, Sulaiman Vesal3
1Institute of Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.
Medical Image Analysis
|February 19, 2025
Summary
ProstAtlasDiff, a novel approach using Denoising Diffusion Probabilistic Models (DDPMs) and prostate cancer atlases, significantly improves the detection and segmentation of clinically significant prostate cancer on MRI scans.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Oncology
Background:
- Magnetic Resonance Imaging (MRI) is crucial for prostate cancer detection, but distinguishing benign from cancerous tissue is challenging.
- Denoising Diffusion Probabilistic Models (DDPMs) have shown promise in medical image segmentation.
- Existing methods lack the ability to incorporate known patterns of prostate cancer distribution.
Purpose of the Study:
- To develop and evaluate ProstAtlasDiff, an enhanced DDPM approach for prostate cancer segmentation on MRI.
- To integrate prostate cancer heterogeneity knowledge into DDPMs for improved detection accuracy.
- To assess ProstAtlasDiff's performance against alternative models and radiologists.
Main Methods:
- Developed ProstAtlasDiff, a DDPM-based model incorporating a prostate cancer atlas to guide noise removal.
- Quantified cancer distribution heterogeneity using a registration pipeline for voxel-level mean and variance calculations.
- Trained and validated ProstAtlasDiff on multi-institution, multi-scanner datasets and compared it with existing models and expert radiologists.
Main Results:
- ProstAtlasDiff demonstrated statistically significant improvements in accuracy (0.91 vs. 0.85), specificity (0.91 vs. 0.84), and PPV (0.50 vs. 0.35) compared to alternative models.
- Achieved higher Dice Coefficient (0.33 vs. 0.31) for more accurate cancer outlines.
- In comparison to radiologists, ProstAtlasDiff detected 16% more clinically significant cancers (sensitivity: 0.90 vs. 0.75) and showed comparable performance in other metrics.
Conclusions:
- ProstAtlasDiff significantly enhances prostate cancer detection and segmentation accuracy on MRI by leveraging cancer distribution knowledge.
- The model shows potential to outperform current methods and assist radiologists in biopsy guidance and treatment planning.
- Further validation in larger cohorts confirms ProstAtlasDiff's superiority over alternative approaches.
