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Preoperative Biopsy Is Not Associated With Adverse Outcomes in Patients With Pancreatic Ductal Adenocarcinoma Undergoing Upfront Resection

  • 0Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
The Journal of Surgical Research +

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February 19, 2025

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February 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative biopsy for pancreatic cancer is safe and does not impact overall survival or treatment timelines. This study found no increased risks, suggesting it is oncologically sound for diagnosis before surgery.

Area Of Science

  • Oncology
  • Surgical Pathology
  • Cancer Research

Background

  • Preoperative histological diagnosis for resectable pancreatic disease is not routine due to concerns about biopsy complications and tumor seeding.
  • This study investigated the oncological safety and impact of preoperative biopsy on patient outcomes.

Purpose Of The Study

  • To determine if preoperative biopsy in pancreatic ductal adenocarcinoma impacts overall survival (OS).
  • To assess the association of preoperative biopsy with 30-day readmissions and return to intended oncologic therapy (RIOT).

Main Methods

  • Retrospective analysis of the National Cancer Database (NCDB).
  • Inclusion of adult patients with clinical stage I-III pancreatic ductal adenocarcinoma undergoing upfront surgical resection.
  • Univariate and multivariable analyses to evaluate outcomes related to preoperative biopsy.

Main Results

  • 57% of 19,361 patients undergoing upfront resection had a preoperative biopsy.
  • No significant difference in median overall survival (OS) between patients with and without preoperative biopsy (23.0 vs. 23.5 months).
  • Preoperative biopsy was not a predictor of OS, 30-day readmissions, or RIOT in multivariable analysis.

Conclusions

  • Preoperative biopsy is oncologically safe in patients undergoing upfront resection for pancreatic cancer.
  • The procedure is not associated with impaired overall survival, 30-day readmissions, or delayed adjuvant therapy.
  • Preoperative biopsy can aid in accurate diagnosis prior to pancreatectomy.

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