Inter-individual variability in muscle sympathetic nerve activity at rest and during exercise: Disconnection with...

Microneurographic recordings of muscle sympathetic nerve activity (MSNA) have provided fundamental insight into sympathetic discharge patterns at rest and during exercise in health and disease. A key feature of MSNA recordings at rest is a large inter-individual variability, even among healthy adults. The physiological consequences of inter-individual variability in MSNA are commonly discussed as being associated with the regulation of resting blood pressure. However, available evidence from large cross-sectional analyses demonstrate a near absence of an association between resting MSNA and blood pressure. Less appreciated, MSNA also exhibits inter-individual variability in response to stress, such as exercise. Again, the consequences of variability in MSNA are unclear and can be dissociated from the blood pressure response, particularly at low-to-moderate intensity muscle contractions for short durations (≤2 min). In this brief review, we summarize several examples of how inter-individual variability in MSNA is unrelated to blood pressure control at rest and during exercise and discuss potential mechanisms responsible for this observation, and key methodological considerations for future study design and interpretation. Additionally, we highlight several unanswered questions that could pave the way for future investigations in the field.