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Updated: May 27, 2025

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized,
Seonghui Kim1, Min Young Um2, Jin-Kyu Han3
1Department of Food Science and Technology, Institute of Food Science, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea; Research & Development Center, Nutra-it Inc., 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea.
Background:
Citrus peels are rich in flavonoids with potential sedative-hypnotic effects; however, these effects have not yet been fully explored. We previously demonstrated that, in mice, standardized lime peel supplement (SLPS) induced non-rapid eye movement sleep and shortened sleep latency through GABAA receptors activation.
Purpose And Study Design:
This study aimed to evaluate the effects of SLPS in adults experiencing sleep disturbances. The randomized, double-blind, placebo-controlled clinical trial involved 80 subjects who received either SLPS (300 mg/day) or placebo for a 2-week period.
Results:
SLPS significantly improved polysomnographic outcomes, including a reduction in sleep latency, wake after sleep onset, and total wake time, and enhancement of sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness, assessed via the Epworth Sleepiness Scale, was also decreased by SLPS.
Conclusion:
No serious adverse effects or side effects were reported among participants in the SLPS group during the intervention period. Our findings support SLPS as a potential natural sleep aid for improving sleep in adults with sleep disturbance.
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