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  11. 3d Printing Personalized Orally Disintegrating Tablets With Complex Structures For The Treatment Of Special Populations

3D printing personalized orally disintegrating tablets with complex structures for the treatment of special populations

Zhiqiang Tang1, Xuejun Chen1, Xiaoxuan Hong2

  • 1College of Pharmacy, Yanbian University, Yanji 133002, China; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

International Journal of Pharmaceutics
|February 19, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

3D printing technology creates personalized oral disintegrating tablets (ODTs) with unique features like braille and QR codes. This innovation offers tailored pharmacotherapy solutions for individuals with special needs, improving medication safety and adherence.

Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Engineering
  • Additive Manufacturing

Background:

  • Personalized pharmacotherapy faces challenges for special populations (children, elderly, visually impaired) due to unique medication needs.
  • 3D printing offers a novel approach for creating personalized drug products with complex designs, enhancing medication safety and adherence.

Purpose of the Study:

  • To utilize binder jetting 3D printing (BJ-3DP) to manufacture acetaminophen oral disintegrating tablets (ODTs) with personalized dosages and complex structures.
  • To assess the feasibility of incorporating patient-specific features like braille, QR codes, and custom designs into ODTs.

Main Methods:

  • Binder jetting 3D printing (BJ-3DP) was employed to fabricate acetaminophen ODTs.
  • Powder and ink formulations were assessed for printability.
Keywords:
Binder jetting 3D printingComplex structuresOrally disintegrating tabletsSpecial populations

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  • ODTs were designed with individualized dosages, embedded QR codes, cartoon figures, text, and raised braille.
  • Internal structures were designed with non-ink-ejecting spaces for a loose powder form.

    • Main Results:

    • Printable properties of powder and ink formulations were evaluated.
    • Characterization of ODTs included porosity, surface roughness, Micro CT scanning, mechanical properties, and in vitro drug release.
    • Successfully manufactured ODTs with personalized dosages and complex surface/internal structures.

    Conclusions:

    • Personalized ODTs with complex structures manufactured via BJ-3DP demonstrate potential as tailored treatment solutions for specific patient populations.
    • This technology can significantly improve medication safety and adherence for individuals with special needs.
    Treatment solutions