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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Improved Assessment of Juxtacortical Lesions in Multiple Sclerosis Using Highly-accelerated High-resolution Double

Tomohiro Shintaku1, Satoru Ide1,2, Haruka Nagaya1

  • 1Department of Radiology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
|February 19, 2025
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Summary

Deep learning-based reconstruction (DL-Speed, DLS) significantly improves detection of juxtacortical multiple sclerosis (MS) lesions using double inversion recovery (DIR) imaging. This advanced DLS-DIR technique enhances lesion evaluation in clinical workflows.

Keywords:
braincortical lesionsjuxtacortical lesionsmagnetic resonance imagingmultiple sclerosis

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Area of Science:

  • Neuroimaging
  • Medical Artificial Intelligence
  • Radiology

Background:

  • Deep learning (DL) techniques, such as DL-Speed (DLS), offer superior reconstruction of undersampled MR data compared to traditional compressed sensing.
  • Double inversion recovery (DIR) is crucial for visualizing juxtacortical lesions in multiple sclerosis (MS).

Purpose of the Study:

  • To develop and evaluate high-resolution DIR imaging using DLS (DLS-DIR).
  • To compare the diagnostic performance of DLS-DIR with conventional DIR (C-DIR) for detecting juxtacortical MS lesions.

Main Methods:

  • Retrospective analysis of MRI data from 25 MS patients.
  • Acquisition of 3D FLAIR, C-DIR (1.3 mm isotropic voxels, ~4 min scan), and DLS-DIR (0.7 mm isotropic voxels, ~4.5 min scan).
  • Two neuroradiologists assessed juxtacortical MS lesions (subcortical white matter, intracortical, mixed) in separate reading sessions.

Main Results:

  • DLS-DIR detected significantly more juxtacortical MS lesions than C-DIR (e.g., Radiologist A: 211 vs. 164).
  • DLS-DIR identified a greater number of intracortical and mixed lesions compared to C-DIR (P < 0.05).

Conclusions:

  • DLS technology facilitates high-resolution, whole-brain DLS-DIR imaging within a 5-minute acquisition time.
  • DLS-DIR can be integrated into routine clinical practice.
  • This method substantially improves the detection and assessment of juxtacortical MS lesions.