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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Updated: May 13, 2026

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Characterizing Brain-Cardiovascular Aging Using Multiorgan Imaging and Machine Learning.

Yalda Amirmoezzi1, Vanessa Cropley2,3, Sina Mansour L4,5

  • 1Systems Lab, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria 3010, Australia yamirmoezzij@student.unimelb.edu.au.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 19, 2025
PubMed
Summary
This summary is machine-generated.

Cardiovascular aging is linked to specific brain network changes in healthy adults. This research explores brain-heart relationships to understand aging diseases.

Keywords:
MRIbrain agebrain networksbrain–heartheart age

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Area of Science:

  • Neuroscience
  • Cardiology
  • Gerontology

Background:

  • Brain and cardiovascular systems undergo age-related changes.
  • Understanding the link between these changes is crucial for aging health.
  • Co-occurrence of brain and heart diseases increases with age.

Purpose of the Study:

  • To determine the extent of the link between age-related brain and cardiovascular changes.
  • To investigate how biological aging of the heart relates to biological aging of the brain.
  • To provide insights into brain-heart relationships in aging.

Main Methods:

  • Utilized normative models and UK Biobank data from 2,904 healthy adults.
  • Estimated biological ages for brain and heart using imaging data.
  • Analyzed structural, morphological, and functional features from brain and cardiovascular imaging.

Main Results:

  • Cardiovascular aging is selectively associated with the aging of specific brain networks.
  • Functional and physiological cardiovascular aging correlates with aging in salience, default mode, and somatomotor networks.
  • Subcortical aging also shows associations with cardiovascular aging.

Conclusions:

  • Cardiovascular aging impacts specific brain networks and subcortical structures.
  • Findings offer insight into the interconnectedness of brain and heart aging.
  • May improve understanding of the increased prevalence of brain and heart diseases in older adults.