Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Autofluorescence and deep learning in early disease detection: biological foundations, clinical applications, and future directions.

Frontiers in artificial intelligence·2026

Same author

Negative-Ion Mode MALDI-TOF MS Combined with Machine Learning for the Rapid Identification of Colistin-Resistant <i>E. cloacae</i> Complex.

ACS omega·2026

Same author

Regular Aerobic Exercise Can Effectively Ameliorate the Skeletal Muscle and Mitochondrial Function Impairments Caused by <i>bves</i> Deficiency in Zebrafish.

International journal of molecular sciences·2026

Same author

Ultrafast and steady-state optical characterization of multilayer PdS<sub>2</sub>.

Nanoscale·2026

Same author

Directional Concerted Proton-Electron Transfer in COFs for Efficient Photocatalytic H<sub>2</sub>O<sub>2</sub> Production.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Serum metabolic biomarkers associated with self-reported chronic rhinosinusitis: a population-based cross-sectional study from the KNHANES.

Brazilian journal of otorhinolaryngology·2026

Search research articles

Related Experiment Video

Updated: May 27, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Role of SCCA and CYFRA 21-1 in the differential diagnosis of sinonasal benign and malignant diseases.

Bingqing Xu¹, Zengxiao Zhang², Lin Wang²

¹Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China; Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, China.

Journal of Cranio-Maxillo-Facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery

|February 19, 2025

Summary

This summary is machine-generated.

Squamous cell carcinoma antigen (SCCA) and cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1) show potential as serum tumor markers. These markers can help differentiate between chronic rhinosinusitis with nasal polyps, sinonasal inverted papilloma, and sinonasal squamous cell carcinoma.

Keywords:

Chronic rhinosinusitis with nasal polyps Cytokeratin fragment antigen 21-1 Sinonasal inverted papilloma Sinonasal squamous cell carcinoma Squamous cell carcinoma antigen

More Related Videos

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Related Experiment Videos

Last Updated: May 27, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Area of Science:

Otolaryngology
Oncology
Biomarker Discovery

Background:

Sinonasal inverted papilloma (SNIP) diagnosis can be challenging, requiring differentiation from benign and malignant sinonasal conditions.
Previous studies suggested serum squamous cell carcinoma antigen (SCCA) and cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1) as potential diagnostic markers for SNIP.

Purpose of the Study:

To further investigate the role of SCCA and CYFRA 21-1 in the diagnosis of SNIP and related sinonasal diseases.
To evaluate the expression of SCCA and CYFRA 21-1 in tumor tissues and serum for differential diagnosis.

Main Methods:

Clinical data and preoperative serum levels of SCCA and CYFRA 21-1 were collected from patients with chronic rhinosinusitis with nasal polyps (CRSwNP), SNIP, and sinonasal squamous cell carcinoma (SNSCC).
Tissue expression of SCCA and CYFRA 21-1 was analyzed using quantitative real-time polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC).
Logistic regression analysis was employed to identify significant serum tumor markers for differential diagnosis.

Main Results:

SNIP patients exhibited the highest serum SCCA levels, while SNSCC patients showed the highest serum CYFRA 21-1 levels.
Tissue analysis confirmed higher SCCA expression in SNIP tissues compared to other groups.
Serum SCCA and CYFRA 21-1 were identified as significant risk factors in the logistic regression analysis for differentiating the three conditions.

Conclusions:

SCCA and CYFRA 21-1 demonstrate utility as serum tumor markers for distinguishing between CRSwNP, SNIP, and SNSCC.
These findings provide a basis for using SCCA and CYFRA 21-1 in the non-invasive diagnosis and differential diagnosis of sinonasal pathologies.