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K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity.

Qiuming Zeng1,2,3,4,5, Hui Guo6,7, Na Tang8,9

  • 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China. zengqiuming1983@csu.edu.cn.

Journal of Biomedical Science
|February 19, 2025
PubMed
Summary

Nedd4 deficiency impairs T helper 17 (Th17) cell responses and autoimmune disease development. Nedd4 targets RORγt for ubiquitination, regulating Th17 cell differentiation and offering therapeutic potential for autoimmune conditions.

Keywords:
Experimental autoimmune encephalitisHECT E3 ubiquitin ligaseK27 polyubiquitinationNedd4RORγtT helper cell 17

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