Protective effect of serum carotenoids on mortality among metabolic syndrome patients: attenuated by lipid-lowering drugs
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View abstract on PubMed
Summary
This summary is machine-generated.Serum carotenoids, including alpha-carotene and lutein/zeaxanthin, are linked to lower mortality in metabolic syndrome (MetS) patients. However, lipid-lowering drugs may weaken this protective effect, suggesting targeted dietary interventions.
Area Of Science
- Nutritional Biochemistry
- Cardiovascular Health
- Metabolic Syndrome Research
Background
- Limited data exists on serum carotenoid-mortality links in metabolic syndrome (MetS).
- The influence of medication use on this association is not well understood.
Purpose Of The Study
- To investigate the association between serum carotenoid levels and all-cause mortality in MetS patients.
- To identify key carotenoids contributing to mortality risk.
- To explore the modifying effect of medication use on the carotenoid-mortality relationship.
Main Methods
- Analysis of 2,521 MetS patients from NHANES (2001-2006, 2017-2018).
- Evaluation of 7 serum carotenoids and mortality data linked via the National Death Index.
- Utilized Bayesian kernel machine regression (BKMR) and random survival forest (RSF) for mixture analysis and key carotenoid identification.
- Employed the 'Qgcompint' R package to assess medication's modifying effects.
Main Results
- Serum carotenoids (individual and combined) showed a negative association with all-cause mortality (HR range: 0.70-0.88).
- Alpha-carotene and lutein/zeaxanthin were identified as significant contributors to reduced mortality.
- Lipid-lowering drug use was found to attenuate the protective effect of serum carotenoids on mortality (P<sub>int</sub> = 0.014).
Conclusions
- Serum carotenoids demonstrate a protective effect against mortality in patients with metabolic syndrome.
- This protective association may be diminished by the use of lipid-lowering medications.
- Dietary interventions rich in alpha-carotene and lutein/zeaxanthin are recommended for MetS patients on lipid-lowering drugs to potentially reduce mortality.
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