Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Unsymmetric Bending01:18

Unsymmetric Bending

299
Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from those in symmetrical bending, and are essential for designing structures to withstand different loading conditions. In unsymmetrical bending, the neutral axis—where stress is zero—does not necessarily align with the geometric axes of the cross-section. The...
299
Bending of Members Made of Several Materials01:08

Bending of Members Made of Several Materials

138
In analyzing a structural member composed of two different materials with identical cross-sectional areas, it is crucial to understand how their distinct elastic properties affect the member's response under load. The analysis involves assessing stress and strain distributions using the transformed section concept, which accounts for variations in material properties.
Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each...
138
Newman Projections02:06

Newman Projections

16.3K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
16.3K
Unsymmetric Bending - Angle of Neutral Axis01:15

Unsymmetric Bending - Angle of Neutral Axis

272
Unsymmetrical bending occurs when a structural member is subjected to bending moments in a plane that does not align with the member's principal axes. This scenario typically arises in beams and other structural components when loads are applied at non-ideal angles, introducing complexities in stress analysis.
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
272
Generation of Straight or Branched Actin Filaments01:14

Generation of Straight or Branched Actin Filaments

2.8K
The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
2.8K
Plastic Deformations of Members with a Single Plane of Symmetry01:21

Plastic Deformations of Members with a Single Plane of Symmetry

86
When a structural member undergoes plastic deformation due to bending, it is crucial to understand the position of the neutral axis and the stress distribution. This member, characterized by a single plane of symmetry, exhibits a uniform stress distribution, with negative stress above the neutral axis and positive stress below. Notably, the neutral axis does not align with the centroid of the cross-section. This misalignment is typical in cases where the cross-section is not rectangular or...
86

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wound, Pressure Ulcer, and Burn Guidelines (2023)-6: Guidelines for the Management of Burns, Third Edition.

The Journal of dermatology·2026
Same author

Live imaging of bacterial actin MreBs from <i>Spiroplasma</i> causing helicity switching of a minimal synthetic cell.

Biophysics and physicobiology·2026
Same author

Systematic Exploration of Synthesis and Function Landscapes for DNA Hydrogels.

ACS synthetic biology·2026
Same author

Protective effects of the selective JAK2/3 inhibitor AG490 against ulcer formation following cutaneous ischemia-reperfusion injury.

Journal of dermatological science·2026
Same author

Conductive Fibers of Chitosan/DNA Interfacial Polyelectrolyte Complexation Incorporating Carbon Nanotubes.

ACS applied materials & interfaces·2026
Same author

Quality of Life in Japanese Men Treated with Intensity Modulated Radiotherapy for Localized Prostate Cancer: Three-Year Longitudinal Evaluation Using Patient-Reported Outcomes of the Expanded Prostate Index Composite (EPIC).

Journal of clinical medicine·2026

Related Experiment Video

Updated: May 27, 2025

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.2K

Wireframe DNA Origami Capable of Vertex-protruding Transformation.

Yosuke Ochi1, Wataru Kato1, Yoichi Tsutsui1

  • 1Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan.

Chembiochem : a European Journal of Chemical Biology
|February 20, 2025
PubMed
Summary

Researchers developed a dynamic wireframe DNA origami that can transform between open and closed states. This breakthrough in DNA nanotechnology enables new possibilities for creating functional molecular devices.

Keywords:
DNA nanostructureTransformationWireframe DNA origamioxDNA

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.0K

Related Experiment Videos

Last Updated: May 27, 2025

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.2K
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.0K

Area of Science:

  • Nanotechnology
  • Molecular Engineering
  • Biophysics

Background:

  • Controlling molecular structure dynamics is crucial for building functional molecular devices.
  • DNA nanotechnology enables conformational changes in DNA origami nanostructures.
  • Dynamic transformations in wireframe DNA origami are challenging due to vertex flexibility.

Purpose of the Study:

  • To engineer a wireframe DNA origami capable of reversible vertex-protruding transformations.
  • To introduce flexibility into wireframe DNA origami for dynamic control.
  • To demonstrate a novel mechanism for dynamic DNA nanostructures.

Main Methods:

  • Designing wireframe DNA origami with spacer strands to introduce flexibility.
  • Utilizing DNA hybridization and toehold-mediated strand displacement for transformation.
  • Employing coarse-grained molecular dynamics simulations to optimize flexibility.
  • Experimental validation using transmission electron microscopy (TEM).

Main Results:

  • Successful assembly of the open-form wireframe DNA origami under optimized conditions.
  • Demonstrated reversible transformation between open and closed forms via strand displacement.
  • Coarse-grained simulations confirmed that longer spacers enhance flexibility for transformation.
  • TEM images validated the structural integrity and transformation.

Conclusions:

  • A novel vertex-protruding transformation mechanism for wireframe DNA origami was developed.
  • This mechanism allows for dynamic control and conformational changes in DNA nanostructures.
  • The findings expand design strategies for dynamic DNA nanostructures and molecular devices.