The pharmacokinetics of the bronchosecretolytic ozothin after intravenous injection

Blood concentrations of the terpenes myrtenal, myrtenol, pionocarveol, verbenon and terbinhydrate in ozothin were investigated as a function of time after intravenous injection of 10 ml ozothin in 36 subjects. On each occasion 10 ml of the terpene mixture was injected into the inside right elbow. During the first 60 minutes after injection several 7 ml samples of citrate blood were withdrawn from the inside left elbow, immediately spun down and analysed by gas chromatography. Elimination of the terpenes from the blood during the first 10 minutes after injection appeared to follow a half-life time of three to four minutes with a second half-life time of 60 to 65 minutes. The concentration of these terpenes in expired air was determined in 27 subjects. Approximately 7% of the substances were eliminated via the lungs during the first 60 minutes. In a further series of experiments the concentration in subcutaneous fat during the first 24 hours after injection was studied. The whole terpenes concentrations range from 2.4 ng terpenes/g fat tissue to 0.8 ng terpenes/g fat at 24 hours.